Robilar's Gambit and Karmic Strike

[F.L.]

Can you combine them? (Provided you have enough AOOs, naturally)

[Azerian Kelimon]

Yes you can. They're a big part of uberchargers.

[the_tick_rules]

yeah, but that's quite a few minuses stackin against you.

[Guy_Whozevl]

yeah, but that's quite a few minuses stackin against you.

With the right build, either your AC is already too low for you to care, or you are so nigh untouchable that it doesn't matter how many penalties you have.