Hmm, this is a bit difficult - I have a very strong suspicion as to who the next major character to die will be, but a few less significant characters will almost certainly bite it first.

So I think I'm going to go with Zz'dtri - I suspect the All-New All-Different Linear Guild is going to take losses up to possibly a TPK, and of all the members, I think he's the most "expendable" and thus most likely to die first.

(By the way, it would make more sense and confuse less comics fans if you called this a Death Pool).