Hmm, there are no modification of Psycho-Essences yet. But, yes, if I were to make a Mind-Immune Piercing Chirurgery option, it would be a niche ability that's more for (mass) damaging purposes than debuffing (so as not to be useless most of the time on a given encounter). All encompassing mind-immune piercing is handled by the Empowering Corruption, anyway, given enough level investments.
Yes, it's an inevitability. Do note the Schism ability though, which renders any such effects irrelevant from a mechanical perspective but may add to a wider roleplaying opportunity..