I think reviewing the new Wonder Twins comic is a good start (its also good). There's only four issues thus far, but the conceit is that Jan and Zan highschool students with a Justice League internship because Superman owes their father a favour. Its mostly goofy superhero stuff, but it also involves a fair bit of highschool drama shenanigans, which are usually the impetus to getting to the superhero action. A look at the slice of life style game is Naomi (a new DC title, which is really good, and doesn't actually involve any superpowers until issue 5).

A Grod mentions its important to know what kind of game you want. Do you want Archie Comics with a superhero background, or do you want X-Men where one wonders how those kids ever get a high school education with all of their adventures.