So this is super-nitpicky, but:

Comic 50 is listed as the first appearance of Tarquin's intelligent axe Soul-Muncher, but the axe he has there doesn't have the red runes Soul-Muncher does. And while that might otherwise qualify as an art upgrade, we actually do see Tarquin's original appearance artistically upgraded in Comic 725, and his axe still has no runes. I'm inclined to think it's not Soul-Muncher and the implication is that he acquired it sometime between then and the present.

I think I brought this up once before, but I don't recall what was said in response.