In fact, between the wilds and the cities it covers most everything that you can come up with for adventures without any alteration of the base setting.
And at high levels is continues to provide challenges to the PC's. Why do the PC's have to deal with the big bad monster out in the wilds? Because most people of their power level are in the cities and don't care about the wilds. Why can't the PC's just gut a city before breakfast? Because that cities collection of high level mages, legions of golems, and other defenses are an actual challenge.