Pain: Initial effect: Sensetivity to pain, every touch hurts (masochists would love it).
Side effect: Inside pain, possibly throwing up.
Secondery effect: the target would be unable to move becuse of pain, and would lay on the floor.
Guilt: Initial effect: feeling guilty for all the wrongs you did in life, and realising what you should have done.
Side effect: feeling guilty on things you shouldn`t feel guilty about, which ends up as feeling guilty for everything.
Secondery effect: doing horrible things just to feel the enormous guilt.
Contemplation: Initial effect: Understanding more things about life.
Side effect: thinking disturbing thoughts.
Secondery effect: Entaring a near catatonic state, in which you (yes you! ) wonder about things endlessly, and it feels like days have passed.

I think the secondery effect should be called withdrawl effect.
Also, save DC 10 is so low that I think only mortals should make drugs that weak.