Threw this together for my thieves guild, I think the amount of options was a little overwhelming for the rogue in my group 😂
I built an entire city around an underground black market Cannon trade.

I have sorted them into 3 “poison kits“ that can create certain poisons rather than worrying about specific ingredients for crafting. Though, I allow for certain poison ingredients to be found while foraging depending on location.

For sake of ease, I have kept the DC to create the poison and the DCsave against it the same.

Applied: 1 action to put on weapon
Ingested: food/drink
Inhaled: think chloroform on a napkin 😈

Cannon, snorted
This substance is distilled from a rare herb called kolkis on another plane of existence and is imported to the shop. It can be sniffed or smoked. Its effects are fast-acting, giving you a burst of energy and alertness as well as making you more sociable and talkative, but the effects wear off quickly. Addiction: DC 14 Constitution, 1d4 Constitution/week; Recovery: six weeks.
Effects: For 1d10 + 10 minutes, you cannot be surprised, and you have advantage on all Strength, Charisma and Initiative checks. Side Effects: You gain a level of exhaustion for 1d4 + 2 hours after the effects wear off. Additionally, you takes 1 point of Constitution damage and 1d3 points of Charisma damage each week the drug is consumed (to a minimum of 1).



Poison Shop:
Basic Poison Kit (10 uses): 50g
Serpent Poison, Crawler Mucus, Assassins Gel, Assassin’s Blood
Advanced Poison Kit (10 uses) - 150g
Allows: Assassin’s Blood, Burnt Othur Fumes, Essence of Ether, Drow Poison, Malice, Pale Tincture, Truth Serum
Master Poison Kit (5 uses) - 500g
Allows: Midnight Tears, Oil of Taggit, Torpor
Distilled Alcohol 1gal - 25g
Blue Lotus x5 - 250g
-Empty Vials - 1g
-Hannan Cigarette - 10g
-Efreeti Smoke(1oz/10 uses) - 150gp
+2CHA for 1 hour. DC15CON or addicted, -2 CHA one week. 25g
-Modron(1oz, 20uses) 50g
sniffed, Advantage Perception/Insight, -1STR for 1D4+1 hours. Disadvant DEX after wears off for 1D2 hours. Addiction: DC16CON, -1D2 STR/week for 4 weeks

Recipes:

Umber Hulk Extract, Applied, DC15CHA or suffer Umber Hulk Gaze, 500g
Must be taken from Umber Hulk.

Assassin’s Blood (Ingested), DC10CON, 1D12 Poison +24hours poison. Half Damage on save. 25g

Burnt Othur Fumes (Inhaled), DC13CON, 3D6 Poison, repeat at start of each turn. Poison ends after 3 successful saves. 75g

Crawler Mucus (Applied), DC13CON, Paralyzed, repeat at end of each turn. 20g

Drow Poison (Applied), DC13CON, Poisoned (Disadvant Attack & Ability) 100g
If the saving throw fails by 5 or more, the creature is also Unconscious while Poisoned in this way. The creature wakes up if it takes damage or if another creature takes an action to shake it awake.

Essence of Ether (Inhaled), DC15CON, Poisoned+unconscious 8 hours. The creature wakes up if it takes damage or if another creature takes an action to shake it awake. 25g

Malice (Inhaled), DC15CON, Poisoned+Blind for 1 hour. 25g

Midnight Tears (Ingested), DC17CON, 9D6 Poison at Midnight, Half on Success. 150g

Oil of Taggit (Applied), DC13CON, Poisoned+Unconscious 24hours. The creature wakes up if it takes damage.

Pale Tincture (Ingested), DC16CON, 1D6 poison, poisoned. Repeats every 24hr. Damage cannot be healed by any means. 7 successful saving throws ends effect. 100g

Purple Worm Poison (Applied), DC19CON, 12D6 Poison, Half on save.
This poison must be harvested from a Purple Worm. 1000g

Serpent Venom (Applied), DC11CON, 3D6 poison or half. This poison must be harvested from a Giant Poisonous Snake. 500g

Torpor (Ingested), DC15CON, poisoned+incapacitated 4D6 hours 150g

Truth Serum (Ingested), DC11CON, poisoned + can’t lie 1 hour. 50g

Wyvern Poison (Injury), DC15CON, 7D6 Poison or half This poison must be harvested from a Wyvern. 500g

-Black Vein Poison Recipe, DC12CON, Applied, 1d3 damage + 2d4 necrotic, 150g
Extracted from the seeds of a dark colored flower that grows from rotting organic matter, the poison has a highly noticeable visual effect upon the victim. The veins closest to the surface of the skin become visibly black, giving the toxin it’s disturbing name, as the poison begins working it’s way through a victim’s bloodstream, turning the blood and the vessels into a rotten black ichor.

Blood Fire, DC12CON, Applied, 2d6 Fire damage, 150gp
Blood-Red Colored Fruit must soak in Distilled Alcohol and Giant Lizard Saliva for 1 day, A reddish-brown sticky paste, this poison has seen a fair amount of use. Once injured, the poison begins igniting the blood, causing a creature to quickly burn from within.

Blue Lotus Extract, Ingested with alcohol, 500g
The blue lotus flower on its own is a powerful hallucinatory drug that causes extreme relaxation, a lack of inhibitions and willpower, and blissfulness. Users often take the drug willingly for these effects. The extract of this drug, if distilled and infused with alcohol, has a magnified effect that can cause imbibers to slip into a catatonic state of euphoria where they become lost in a dreamlike of pleasure and ecstasy for 2d4 hours. Creatures under the effect of the drug feel little pain, gaining 4d8 temporary hit points for the duration of the drug. The drug does require a successful DC 18 Constitution saving throw to avoid random attacks by shadow creatures.
The shadow creatures are figments of the character’s mind, having the same hit points and attack modifiers of a shadow. Damage suffered by the character is real in so much as the character damages himself or herself trying to fight things that are not there. Three consecutive failed saving throws results in addiction to the substance. Addicts must take the drug as soon as it wears off or lose complete control of their actions until such time as a new dose of the drug is taken.

Concoction of the Pallid Serpent, Ingested, DC14CON, 1minute, 2d6 psychic, -1Wis, 400gd
Created from the paste made by grinding up leaves of the Cat’s Breath plant, and combined with the pungent juice made from King’s Pear seeds. Upon ingestion, the victim begins experiencing terrible headaches and visual hallucinations. They often see things twisting and warping, with vile and hideous creatures seeking to cause them harm. Those in the throes of the poison often lash out at those around them, believing that they have suddenly been surrounded by monstrosities

Death Flower Oil, contact/ingest, DC18CON or brought to 0, success 8d6 poison, str drained by 1d4 until long rest. 5000g
DC20 to create
Death flower oil is a complex distillation of black lotus and deadly nightshade berries that has been boiled down into a syrupy oil. So deadly is it that handling it can cause instant death to the user.

Desert Lotus Poison, ingest, DC15CON, Hallucinatory Sleep 2D12 hours = 1D4 wis/int damage
Success on CON grants advantage against fear and charm for 1D4+4 hours. Within 6 hours of eating you drop to 1hp intead of 0. 100g
This wild plant grows with fiery orange flowers. Wild brigands of the desert consume it in order to enter a narcotic trance that makes them very ferocious and more difficult to kill.

Distillate of Nightmare, applied, DC18CON, 4D6 Psychic, comatose for 2D6 hours. Awaken with 1D10x10 hours of Paranoia. 1000g
Must Loot Myconids for Fungal Remains and distill in alcohol for 1 day.
Distillate of nightmare is a powerful poison made from the distilled remains of murdered fungus folk. The powdered remains are highly toxic to the central nervous system.

Dust of the Desert Winds, Inhaled/Ingested, DC15, 2D6 Poison, 50g
This insidious powder has long been the favored poison of assassins that dwell in the harsher climates of the world. Created from grinding up the Sand Mushroom that only grows in a small cave system at the edge of the dunes, the toxin begins immediately leaching all of the moisture from a victim’s body after it has entered through the mucous membranes. Once dead, the victim is little more than a dessicated husk.

Efreeti Smoke, Inhaled, +2CHA for 1 hour. DC15CON or addicted, --2 CHA one week. 25g
This reddish gold tobacco has a spicy, heady flavor, and produces a thick yellowish smoke from the imbiber. Smoke is a highly addictive substance that fills the smoker with euphoria and a heightened sense of self.
Side Effects: The stench of the smoke tends to make others wish they were anywhere but in your presence.

Ergos, Ingested, 50% chance no action for 2D4 hours. 250g
-1D4 Dex until long rest, Addiction DC16 -1D4WIS/week for two weeks.
This substance is harvested from the ergos fungus, crushed and boiled. The resulting liquid is then consumed. The effects are felt almost immediately and last for quite a while, filling your mind with vivid and rich hallucinations, making everything around you seem more vibrant, colorful, and enriching.

Ghost Blossom Extract, Applied/Ingested, DC12, 2D4 Poison + 2D4b, 200g
Created from the juice of a pale white flower that only blossoms at night, the poison elicits violent muscle contractions.

Hannan, ingest/inhale, Advantage on INT/CHA, Disadvant STR/WIS for 1D2 hours, 100g
This yellowish tobacco has a sweet taste and odor to it. You experience hallucinations. Hannan is not addictive.

Jade Frog Poison, Ingest/Applied, DC14CON, 1 hit, 2D4 Poison, 150g
Once the poison has entered the victim’s system, the victim begins suffering from itching, and lesions begin to form upon their flesh.

Jena, ingest/inhale, Advantage DEX/initiatie, Disadvant WIS for 1D4 hours, 150g
You feel a rush of energy and adrenalin spread throughout your body. Jena is not addictive.

Jellyfish Toxin, ingest/injury, DC15CON, Fail: Paralyzed for 2D6+2 Hours. Success -1D6 STR for 2d6+2 Hours.
Found foraging at Ocean Coastline/fishing at sea.
A lesser restoration spell or similar ability removes its effects.

Kesh-aath, ingest/inhale, Advantage CHA, disadvant WIS for 1D2+1 hours. Addiction DC18: -1D2STR/week for 3 weeks. 150g
Available in DUNES

Libynos Blue, Inhaled, DC14CON or sore throat for 1D4 days. User travels on half rations. 50g
Libynos Flower Sold in DUNES
Najala, inhaled, +2 STR, -2CON for 1D4 Hours
Sold in Dragonfell

Orange Poppy Blossom Pollen, inhale, DC17CON or sleep until moved from area. If trapped in a small area for 1hour, dies of dehydration 2D10 minutes recovery and become exhausted 1.
Found while foraging in pink forest.
Purple Lotus, ingested, DC16CON 5D6 Poison. Survivor suffers 1D3 Wisdom + Legend Lore
Psychedelic Plant

Tears of the Infernal, Applied, DC16CON, 2D6+2 Acid, 250g
Harvested and distilled from the oozing sap of the Weeping Cactus that dwells in the most desolate deserts in the world, this oily poison dissolves organic material upon contact.

Witchbane, DC12 to craft, Applied, DC15WIS, 1 Round, Lose Highest 1D4 Spell Slots + 1D6 Psychic, 750g
A creation that seems to have been specially devised just to hamper arcane spellcasters, once injured by a weapon slathered in the poison, the toxin goes to work by first destroying the knowledge of the highest level spell slots remaining in the caster’s repertoire. After stripping away the most potent spells from their mind, the poison then begins to inflict damage upon the victim’s psyche.