Quote Originally Posted by Nomar View Post
I was trying to express two separate lines of thought there, and one didn't quite make it through.

The idea was that Twilight is the only pony in the group who didn't grow up in or near ponyville, and also the only one who didn't react to Zecora with fear — fear of evil magic specifically. To me, that suggested a local superstition (the existence of curses as a specific kind of magic) that Twilight doesn't share, so that's what she might have meant with curses not existing.

And now that I typed it all up I think I made things more complicated than necessary. A much simpler explanation is that Twilight was in a state of panic and grasping at straws.
I just think she's generally skeptical, while her friends aren't.