If you mean shipping-wise, then yes, and that's kind of the point. Flutter and Dash don't seem to be personality and viewpoint-wise similar enough to play off each other well and it all goes down to friend and regular-ships.
If you mean in the series, Playing Twilight off Pinkie is pretty common... like... it starts at "it was under 'E'" to all of season two and continuing on.
edit- RYB is a holdout from back before things were really understood. It's mostly sticking around as a cultural artifact, kind of like how silly imperial measure is