I had a swashbuckler who seduced an amethyst dragon in an attempt to save the party. The dragon was so intrigued by the sight of a mortal who a) didn't cower in terror, and b) actually tried such a bold ploy, that she didn't eat the party.

This was in second edition, with a maxed-out charisma and the swashbuckler kit gave a bonus to NPC reactions from the opposite sex. By the RAW, his natural sex appeal was at least enough to overcome her natural tendencies. He even meant what he was saying (unfortunately) and was not just trying to save his own skin.