There are a number of those nuclear heads you can detonate remotely, you should be familiar with the mechanic by now. Instead of immediately hitting them all, wait until after the fight starts. Some of the enemies spawn around them, and you can take out a pack at a time using them offensively.
Other than that, how you handle Ulysses will determine how the fight proceeds. And you have a rather big choice to make, and not much time to make it in. This will have lasting consequences on your game which will open, or deny, areas permanently. No take backs.