Mechanically? I'd like to build a character who would be able to drop everything they have into a single attack. When taking on deities it's often the case that Gods are only vulnerable for a brief period of time, if maybe only for a moment, so these single attack builds are what I'd consider to be very fluffy and appropriate for taking them down.

Probably some kind of Hexblade/Paladin multiclass with Grave Cleric thrown in to set up the death strike.