Originally Posted by
Gnoman
Problem #1 is a much nastier one. Black powder is easy to make if you know the recipe, while you can load most guns (Glocks being the most prominent exception - they'll explode) with cast lead bullets. Casings are harder to make, but are reusable. That's 3 out of the 4 essential parts for a cartridge gun. The last one's a doozy.
See, to make the cartridge go off, you need something that will explode when struck by the firing pin - in cartridges this is called a "primer", while loose examples are "percussion caps". These are not easy to make. Fulminate of mercury requires toxic (and generally difficult to find) ingredients, a fairly involved process, and not detonating it can be difficult. Potassium Chlorate is safer, but still not easy to produce. If you can't manage that, you'll have to revert to loose-powder flintlocks.
Once you've solved that, you can decide what your best options are. Black powder can't attain the same velocities as nitro can, so big, heavy bullets are the way to go. This means that your post-apoc setting will have a very "Old West" fell to the weaponry.