Doom Patrol was a 1963 comic book before it became a TV show.
And If you want another adaptation example - Umbrella Academy added genderfluidity and queerness that wasn't present in its source material either, without hurting its popularity.
I didn't mention neutral because then it will likely just come down to what the showrunner feels like doing. Again, with the five examples (three being adaptations) I mentioned previously, somebody made the decision that audiences would either enjoy the portrayals or not care much. I think the same could happen here.
What "first" comes to mind for anyone isn't relevant to me, so long as it does.
Pretty sure every property I listed was released on a major network, not a "niche market."
As Glyphstone helpfully suggested, I'm leaving this well alone.