You might check out Dragonstar, which was a Fantasy Flight Games campaign setting for D&D 3.0 that never got updated. You can get a few of the books from DriveThru, but the rest seem to have vanished. But it is very much D&D in space (real space, not fantasy space like Spelljammer had).
While it is never mentioned, the movie Ice Pirates always come to mind when I read the Dragonstar material.