Originally Posted by
Storm_Of_Snow
Your main problem then becomes the current colonist educating their successor while maintaining all of the colony's resources, especially the cloning equipment. And if you start to get problems with that process, or if the current colonist suffers an accident, then that colony is on the way out.
Plus it's not necessarily guaranteed that the new clone will have the same mind set as their forebear.
One female colonist with IV tech and a supply of X chromosome spermatazoa might work (and a group version of that might be a way of supporting a maintenance crew for a generation ship), but again, you're hoping they don't suffer some injury that shortens their life or leaves them infertile, and twins or other multiple births might seriously stress the available resources.