Go into it blind. It's such a great experience when you're exploring and discovering everything the first time.
If you find yourself stuck and don't know what to do, either listen to radio messages or look for ways to go deeper.
Oh. Also play on the filmic setting if you can tolerate it. It decreases visibility but makes the colors more vibrant and amps up the atmosphere. It's how the game is meant to be experienced.
If the decreased visibility is bothering you then you can turn it off, but I would at least try it first.