Quote Originally Posted by Tvtyrant View Post
Pretty easy depending on setting. A single alien, people stuck with it inside a space station for a season. Pick up ques from Walking Dead; the Alien is an environmental threat, the real issue is the humans are having group conflicts and killing each other. Instead of working together to kill the monster they are focused on their political/resource issues, so the monster picks people off one by one.
This, but also you get to explore a few layers that Walking Dead couldn't - in Alien, government is ineffective not because it has totally collapsed, but because it was eroded into irrelevance by hypercapitalist corporations before the xenomorphs even showed up. Where Walking Dead devolved into a repetitive cycle of "ragtag group stumbles into safe community/stronghold area, makes enemies of nearby charismatic yet sociopathic warlord, tensions escalate until stronghold/community is no longer viable and walkers chase them to the next area" with no endpoint in sight, an Alien series would have a built-in overarching villain (e.g. the corporation itself, perhaps with a corrupt executive or division head as the face of our heroes' suffering, or - as was the case in Alien Isolation - acting through a near-omnipotent AI with no regard for human life) with several endpoints we can build towards - such as causing them to cut their losses, pin everything on said executive/AI while otherwise getting away with it all, collapse entirely, or even reform. The AI itself could also be a wild card faction could side with or against the heroes in a believable way on occasion.

From a purely practical standpoint, it would also be easier on the cast since you can have some technology around to explain convenient things like how they can shower, brush their teeth, have sex, treat injuries and illness, raise families etc. You could still have dangerous "supply runs" into infested territory like Walking Dead does, and overarching goals for the heroes besides mere survival like "repair the comms array" or "gather evidence to take down the corporation."