Bonfire specifically states that the bonfire fills a 5' cube and that creatures must be in its space to take damage. Hypothesising about how hot a real 5' fire would be is off the mark.
To affect 4 creatures in a 2×2 arrangement, you place the bonfire presumably in the middle, where one quarter of it intersects with one quarter of each creatures' space.
I play and DM. I wouldn't expect this to work as a player. As a DM I assume you simply pick a square for it to affect. If a player agitated otherwise, I'd give advantage on the save.
I'll be honest though: I actually just use 3.5 edition spell areas for grid play.
Edit:
You get a save no matter how much of your space is covered by an area effect.