Honestly, it's probably even more lopsided than Goku vs. Hercule- Hercule could... at least theoretically... have some potential to hurt Goku, no matter how remote. Homelander, unless he learns magic or gets dipped in Kryptonite or something, would have about as much chance of hurting Superman as a bug would of... hurting Superman.

And even if Homelander got his hands on lots and lots of Kryptonite, Superman has successfully beaten a guy that was made of the stuff, so, uhm...

Yeah. No contest.