If we're talking the strongest version of Superman vs Homelander then yeah it's not even worth discussing. Homelander is a middling powerhouse who happens to be impressive by mortal standards, sure. But Superman is strong enough to punch the universe into retconning, fast enough to escape the gravitational pull of a black hole, and tough enough to take a nuke to the face without much problem even in some of his weaker incarnations.
...but if we're talking "more powerful than a locomotive, faster than a speeding bullet, able to leap tall buildings in a single bound" Superman, that's probably more of a fair fight? And sure that's probably not what OP meant, but also
Superman has lost battles on occasion when by all accounts he shouldn't have even been inconvenienced.