Why start there? The worst offender is Deathwatch:
Use this Stratagem vs. Aeldari,
Use this Stratagem vs. Orks,
Use this Stratagem vs. Necrons,
Use this Stratagem vs. T'au Empire,
Use this Stratagem vs. Tyranids.
If my opponent plays a Xenos race, I get to use one of them. But, my opponent 'this game' is currently playing Astartes, so I guess I'll go **** myself? However, on the reverse end, Deathwatch have a guaranteed maxed Secondary if they're up against Xenos...But that only works if Xenos are the meta - which they aren't.
A similar pain has been by Grey Knights in every edition. Your opponent doesn't play Daemons? That's cool. Depending on the edition, a significant percentage of the abilities you non-optionally pay points for, don't even work. That's why when Custodes came out, their gimmick was "We're like Grey Knights, but we work against everything." Spoiler alert; Custodes are really, really strong.
Similarly, you've got Aeldari vs. Slaanesh. When it doesn't work, it does nothing at all. When it is applied, it's a guaranteed loss. Sweet mechanics!
Same thing with the aforementioned Deathwatch Secondary. Most of the time it wont do anything at all. When it does apply? That's a GG by Turn 2.