"A creature with this special quality ignores damage from most weapons and natural attacks. Wounds heal immediately, or the weapon bounces off harmlessly (in either case, the opponent knows the attack was ineffective)."
That would be from the systems reference document.
Now, I misrembered some details about using twohanded weapons, but I think you get my point.
Okay, how about this: You're asking Jackie Chan in his prime to beat up Luke Cage with her bare hands.