Had the strangest experience: the newest version basically slowed my laptop to a crawl, while the older ones were a light jog. So it's possible, but you'll maybe have to take care not to install expansions and go lightly on the graphic details.
Still, KSP is KSP. I always return to it. There is an inherent pleasure in sending small, scared cucumberfolk into space.
Same with Dwarf Fortress, ADOM, Jalopy, Banished and Mount & Blade: Warband.