Archer is about living with autism.

Let's get the obvious out of the way: I one episode, Lana flat out says that she thinks that Sterling is autistic and explains why, and by the end of the episode Sterling admits that she might be right after examining his own behavior...

But that's sort of presented as a joke, so let's take a deeper look.

Let's look at Sterling Archer: It would be easy to dismiss him as a moron... If not for the sheer genius he demonstrates whenever he is properly motivated or in his element. Archer has extreme difficulty functioning in society and is very bad at picking up social cues or engaging in acceptable social behavior, but when he knows what's going on or when its' something he's good at...Like for example, being able to easily keep track of how many bullets everyone has fired in the middle of a hectic gunfight. Or inflicting violence on people.

Archer can switch between rational adult and gleeful child at the drop of a hat, particularly if something of interest to him comes up. Like guns. Or animals. (See, his reaction to finding out that Cheryl has an ocelot.)

When he decides to be helpful, he tends to overdo it... When he found out that Lana was pregnant, for example, he began researching everything that could possibly go wrong with a pregnancy and got certified as a midwife just in case, which is above and beyond, and proposed to her so that the kid would have a father.

He doesn't form bonds easily, but when he does... See his relationship with Pam, which quickly goes from him not caring if she lives or dies to her being easily his best friend over the course of a few years.

Archer often has a very strange logic... But not an invalid logic. For example, when questioned about why he didn't realize that his chemotherapy drugs were fake when he realized that the pills were chewable, Archer states that he assumed that they were chewable because small children get cancer and if they need that medication they might not be able to swallow full-sized pills, which Krieger accepts as a valid point.

So like, between all of that and his episodes of savant behavior, I'm not a psychologist but there's probably enough to diagnosis him: Sterling Archer is autistic.

Now, moving away from the hard evidence to more thematic points: Everyone in I.S.I.S., Fergil Investigations, or whatever the group is going by that season can be argued to either be someone just as dysfunctional as Sterling, or else can be read as a normal person being seen through the eyes of someone who doesn't "get it." Some are both.

As an adult, Sterling is literally being taken care of: He has a live-in domestic servant who does all of his day-to-day work for him and his mother pays for his living arrangements, which is a common thing with people with disabilities and disorders of all kinds.

As a child, Archer had a mother figure who facilitated between apathy to his needs and active abuse to try and control him and a father figure who cared but couldn't give him what he needed. Both are distressingly common among autistic children and both can result in an autistic individual being less than functional... And several episodes basically spell out that his mother's alternating neglect and abuse are responsible for most of how Sterling is as an adult.

In the final season, everyone else uses Archer's presence as an excuse to be their worst selves, and it's not uncommon for people who have social disabilities or who are just socially awkward in general to be used as scapegoats in that exact manner.

While Archer does have a degree of character development, particularly after becoming a father, there are numerous points in the series where he tries to better himself only to backslide or run into roadblocks due to being in a toxic environment which is another thing that's distressingly common not only among autistic individuals but among people trying to become better at being people in general.

A.J., when seen in the last season, has a lot of Archer's behaviors and mannerisms despite having effectively never met him, as he went into a coma when she would have been too young to remember him beyond maybe vague details. She doesn't even know that Sterling is her father. Autism is believed to be caused by genetic factors, and it's not uncommon for certain behaviors to run in families.