Howard the Duck??
The comic wasn't bad (especially for its day), but it really wasn't for everyone. The original film while fun to watch, was a little wonky, and very detached from the comic. Perhaps it would work as animation.
Some of the old "what if" comics were very good, but it could be very hit and miss. They worked because it was all limited to one issue. This might work as long as they keep the same sort of limitation.