Quote Originally Posted by Elves View Post
You can't get too specific though if the game is meant to cover a wide variety of physiologies. I would make it abstract, something like each injury gives -1 on d20 rolls, which can be replaced (or augmented?) with a debuff from a set list. You inflict a wound and select the -10 ft speed debuff. That could mean that you hit their legs, could mean you concussed them -- fluff it how you like.
Careful, that's how you get 4e-style pearl clutching over standard penalties on non-standard anatomies.