I'm beginning to think ol' Jephy-boy has some particular interests. Hey, it's his webcomic.

More seriously, there's definitely a dissonance in their vibes, but I've seen that work just fine before. Once they pick something to play/do, they'll probably settle into a dynamic pretty fast and build from there. Or they'll spend the entire stream faffing about and wind up not actually doing much, which will somehow wind up being immensely popular regardless. Collabs are funny that way.