This one kind of makes sense. I have a very, VERY limited experience of vtubers, but from what I have seen their platform is incredibly incestuous even if you don't take into account networks, wikis, and collab-groups with a shared agent or sponsor.
They're both presenting as cis female, they're both American, and they're both independently 'internet famous' above a certain level. Streamers build collabs from WAY less common ground, and them being in a niche community seems like enough of a handwave.
As for everything else... Yeah, pretty much. This is what the comic is now - it's not been about indie rock loving 20-somethings getting into weird situations for about 2000 strips, and it's not going back.
Although I have to admit, the Giga-Chad-Cow face in today's strip is both overwhelmingly horrific, and yet absolutely perfect. Jeph deserves credit for really capturing the degeneracy of Youtube Thumbnail Face, which is separate from but as similarly untreatable as Butts Disease.