Is there any reason that the 1e rules can't just be used in 2e games? The core system didn't really change in the entire 40kRPG run (which I personally separate from Wrath & Glory).
But yeah, creating a Daemonhost is the most Radical thing an Inquisitor can do, likely gets then ostracised by half of their peers (at minimum), and any loyal Imperial who gets wind of it would likely start looking to kill the Inquisitor (discretely) and Host (maybe not so discretely). Sorcery itself is generally bad enough.
That's not getting into the impression I got from the wargame and lore that Inquisitors mostly made them as highly bound mostly disposable weapons. Even if your Willpower and bindings are high enough to keep you in control you're on a much shorter leash than any other acolyte, with much more scrutiny put into every one of your actions. If it seems like you're not under control probably the least you can expect is a squad of stormtroopers.