Most books and an even higher percent of movies are told from the POV of the protagonist, which locks the plot into their POV. Books and movies are generally a bad source of plot inspiration, I think most gamers would accept that as true. Settings are what most people take as inspiration from books, films and videogames.
The reason why Charade works as a plot that can be transplanted into a game is that the protagonist (Audrey Hepburn) is essentially a passenger and weird stuff she can’t control happens to her. Monkey Business (the Marx brothers film, not the Marilyn Monroe one) works because it is a genuine ensemble piece from the start and the plot is an excuse to setup the Brothers unleashing chaos.