I'm not sure why you think this. A show about the internal politics of the Imperium would have the advantage of being cheaper (less need for giant set piece CGI battles) and the format has been shown to be very popular with audiences. Their marketing guys will certainly be happy to call it "Game of Thrones in space." And there's no reason why it would have to be "politically charged", since (like Game of Thrones or House of the Dragon) the politics of the 41st Millennium have nothing to do with real world modern day politics, and the only reason those keep coming up in fantasy/sci-fi shows where they don't belong is because the writers are hacks (and if those people are on the writing staff, they'll shove them in there regardless).
You could quite easily make a show about a conflict between (roll a die twice and pick from below) and have no problem coming up with a reason for the conflict or way in which it can play out, with Tzeentch pulling the strings of one or both sides.
1)The Iquisition
2)The Mechanicus
3)An IG Regiment
4)An admiral in the Navy
5)An admiral in the local SDF
6)A general in the local SDF
7)Another general in the SDF
8)A Space Marine Company
9)The Ecclesiarchy
10)The Administratum
11)Another Space Marine Company
12)A different branch of the Inquisition
13)A planet's local royalty
14)A different inquisitor in the same branch of the Inquisition
15)The Commissariat
16)A slightly heretical cult of the Emperor
17)A Navigator House
Castes are Not Real Communism^TM, just like everything else, mostly on account of communism being really vague when it comes to actual implementation details. Finding two communists who actually agree about what "real communism" is no easy task.