In my last campaign we came up against them semiregularly.

The first one killed the warlock but the rest of us managed to stay behind cover and whittle it down with ranged weapons and cantrips while it disintegrated our cover and tried to force us out into the open

Second time we had a bunch of NPCs along with us absorbing the direction of the antimagic cone so it was a much easier affair even if we had to dodge the occasional eye ray

Third time was my favourite, three were descending a chasm chasing us but the paladin was also trying to catch up and ended up behind them at the top of the chasm, dropping boulders on them they could do little about due to speed and range. They ended up carving a tunnel in the rock wall with disintegration in order to get away and we had to hustle to meet in the middle (flight, spiderclimb and dimension door) and chase them down in that tunnel before they could get away. That was much more gruelling but the paladin had great saves (of course) and we were fresh on resources for that fight so we could nova them.