I dont think magically roofying an entire building can be brushed off so easily just because the main character nat20-ed her Will save after a few rounds.
Thankfully there are pretty strong evidence on that an entire building has in fact not been matically roofied.

Its quite plausibly that the comic does not run on d&d rules.
If thats the case, then that arguably one of the weakest willed and most impulsive people can shake the effect off.
Shows that the effect isnt that strong.

Just.. if you wish to kiss someone. And they suddenly also want to do it.
Then either part is very likely to try and resist the urge.