By "Lose" I mean "Rendered their planet uninhabitable", they still know where it is, it's just a blasted toxic hellscape that can support no life and is roamed by the Nanobots they built in order to fight a minor plague. The Disease mad them throw up, feel ill, and die in maybe 5% of cases. The cure (Nanobots) had trouble telling the difference between the bacteria, any other bacteria, or really any other organic matter.
Then somebody decided to try Nuking the areas infested by the Nanobots. That didn't help either.
Edit: I might reshape them from Used Car Salesmen to more Mercenary scientists. They're Brilliant, but with the loss of their homeworld they are shattered, and they are often very distrustful of their own technology. Their old specialty was Nanotech, but those that survived have a hatred for it. They seek to purge all of their own Nanotechnology that's still around in the galaxy. However, for the last couple hundred years they had been boosting themselves with Nanotech, so those that are left who purged themselves, are very weak.
Of course, there are still "Tech Heads", those that use the old Nanobots, often they've boosted themselves past safe levels, making them very dangerous and in some cases half mad.
Edit 2: Ooh, a storyline could be centered around some people getting onto the planet and collecting some of the Nanobots, threatening to release them as a "Nanobomb"