Alignment-free D&D?

[Siosilvar]

Is there any major game-play effect that I'm missing? Other than that on paladins? I'm thinking of leaving in the [Good]/[Evil]/[Law]/[Chaos] tags, but only for the appropriate outsiders.

No, not really. Incarnates, Soulborn, and Crusaders will get a little more variety, but not much else will change.