I tend to play characters on the 'middle' axis, i.e. NG, N, and NE, with a tendency towards N. I like wizard-y characters. Oddly, I've never played a druid in a full campaign. True neutral seems to be the most natural adventuring alignment to me. If mister Cleric of Pelor is so good and awesome, he needs an extra reason for him to go heal up grave robbers instead of curing the sick in his hometown. Badguy McEvilpants needs additional justification not to stab his friends in the back, and the friends need that justification to trust him.

With neutral characters, on the other hand, it's easier for me to give them simple motivations like "I want treasure, fame, and glory" without those motivations being dominated by other pressing good deeds, and without them becoming a hindrance to party cooperation and the advancement of the story.

Obviously these issues are solvable, but it requires some effort.